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Int Urol Nephrol. 2012 Apr;44(2):639-42. doi: 10.1007/s11255-010-9878-5. Epub 2010 Nov 27.

Systemic mastocytosis presenting with acute oliguric renal failure: report of a case and review of the literature.

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  • 1Pasadena Nephrology Corporation, Pasadena, CA, USA.


A 61-year old African-American woman presented with abdominal pain, tender splenomegaly, anemia, and renal insufficiency. Bone marrow biopsy demonstrated systemic mastocytosis. She was treated with mediator-specific therapy and imatinib, but her renal and hepatic function deteriorated and she required maintenance hemodialysis. Renal biopsy demonstrated interstitial infiltration with mast cells and acute tubular necrosis. Acute kidney injury in the setting of systemic mastocytosis and imatinib therapy is discussed.

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