Nat Cell Biol. 2010 Dec;12(12):1126-8. Epub 2010 Nov 21.

Dynein at odd angles?

Abstract

Cytoplasmic dynein drives vesicular transport from the periphery to the cell body of neurons. Missense mutations in the dynein tail domain cause neurodegenerative disease in mouse models. new data on the effect of one such dynein mutation provide insight into the intramolecular communication and flexible stepping of this essential cellular motor.

Comment on

Nat Cell Biol. 2010 Dec;12(12):1228-34.

PMID:: 21102436; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Dyneins

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

A cytoplasmic dynein tail mutation impairs motor processivity. [Nat Cell Biol. 2010]
A cytoplasmic dynein tail mutation impairs motor processivity.
Ori-McKenney KM, Xu J, Gross SP, Vallee RB. Nat Cell Biol. 2010 Dec; 12(12):1228-34. Epub 2010 Nov 21.
The legs at odd angles (Loa) mutation in cytoplasmic dynein ameliorates mitochondrial function in SOD1G93A mouse model for motor neuron disease. [J Biol Chem. 2010]
The legs at odd angles (Loa) mutation in cytoplasmic dynein ameliorates mitochondrial function in SOD1G93A mouse model for motor neuron disease.
El-Kadi AM, Bros-Facer V, Deng W, Philpott A, Stoddart E, Banks G, Jackson GS, Fisher EM, Duchen MR, Greensmith L, et al. J Biol Chem. 2010 Jun 11; 285(24):18627-39. Epub 2010 Apr 9.
Drosophila cytoplasmic dynein, a microtubule motor that is asymmetrically localized in the oocyte. [J Cell Biol. 1994]
Drosophila cytoplasmic dynein, a microtubule motor that is asymmetrically localized in the oocyte.
Li M, McGrail M, Serr M, Hays TS. J Cell Biol. 1994 Sep; 126(6):1475-94.
Review Cytoplasmic dynein/dynactin function and dysfunction in motor neurons. [Int J Dev Neurosci. 2006]
Review Cytoplasmic dynein/dynactin function and dysfunction in motor neurons.
Levy JR, Holzbaur EL. Int J Dev Neurosci. 2006 Apr-May; 24(2-3):103-11. Epub 2006 Jan 6.
Review Cytoplasmic dynein could be key to understanding neurodegeneration. [Genome Biol. 2008]
Review Cytoplasmic dynein could be key to understanding neurodegeneration.
Banks GT, Fisher EM. Genome Biol. 2008; 9(3):214. Epub 2008 Mar 28.

See reviews... See all...

Recent activity

Clear Turn Off Turn On

Dynein at odd angles?
Dynein at odd angles?
Nat Cell Biol. 2010 Dec ;12(12):1126-8. Epub 2010 Nov 21 .

PubMed
Mechanical stochastic tug-of-war models cannot explain bidirectional lipid-dropl...
Mechanical stochastic tug-of-war models cannot explain bidirectional lipid-droplet transport.
Proc Natl Acad Sci U S A. 2011 Nov 22 ;108(47):18960-5. Epub 2011 Nov 14 .

PubMed
A cytoplasmic dynein tail mutation impairs motor processivity.
A cytoplasmic dynein tail mutation impairs motor processivity.
Nat Cell Biol. 2010 Dec ;12(12):1228-34. Epub 2010 Nov 21 .

PubMed
Three-dimensional structure of the radial spokes reveals heterogeneity and inter...
Three-dimensional structure of the radial spokes reveals heterogeneity and interactions with dyneins in Chlamydomonas flagella.
Mol Biol Cell. 2012 Jan ;23(1):111-20. Epub 2011 Nov 9 .

PubMed
The mechanism of dynein motility: Insight from crystal structures of the motor d...
The mechanism of dynein motility: Insight from crystal structures of the motor domain.
Biochim Biophys Acta. 2012 Jan ;1823(1):182-91. Epub 2011 Oct 28 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Dynein at odd angles?

Abstract

Comment on

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information