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Islets. 2010 Jul-Aug;2(4):261-2. doi: 10.4161/isl.2.4.12028.

Seeing is believing: how the MIP-luc mouse can advance the field of islet transplantation and β-cell regeneration.

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  • 1Department of Surgery, University of Chicago, Chicago, IL, USA.


In the last five years, bioluminescence has emerged as a vital tool in the non-invasive quantification of beta-cell mass following islet transplantation in murine models. The successes achieved in bioluminescence imaging in islet transplantation has prompted its use in the discipline of beta-cell regeneration. Employing bioluminescence permits quantifying changes in β-cell mass in an individual mouse over time, which can provide valuable insights into the kinetics of beta-cell regeneration.

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