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Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2820-4. doi: 10.1073/pnas.1010559107. Epub 2010 Nov 22.

Altered antisense-to-sense transcript ratios in breast cancer.

Author information

  • 1Department of Medical Oncology, and Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Abstract

Transcriptome profiling studies suggest that a large fraction of the genome is transcribed and many transcripts function independent of their protein coding potential. The relevance of noncoding RNAs (ncRNAs) in normal physiological processes and in tumorigenesis is increasingly recognized. Here, we describe consistent and significant differences in the distribution of sense and antisense transcripts between normal and neoplastic breast tissues. Many of the differentially expressed antisense transcripts likely represent long ncRNAs. A subset of genes that mainly generate antisense transcripts in normal but not cancer cells is involved in essential metabolic processes. These findings suggest fundamental differences in global RNA regulation between normal and cancer cells that might play a role in tumorigenesis.

PMID:
21098291
[PubMed - indexed for MEDLINE]
PMCID:
PMC3286925
Free PMC Article

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