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Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21812-7. doi: 10.1073/pnas.1010373107. Epub 2010 Nov 22.

Alzheimer's disease peptide beta-amyloid interacts with fibrinogen and induces its oligomerization.

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  • 1Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY 10065, USA.

Abstract

Increasing evidence supports a vascular contribution to Alzheimer's disease (AD), but a direct connection between AD and the circulatory system has not been established. Previous work has shown that blood clots formed in the presence of the β-amyloid peptide (Aβ), which has been implicated in AD, have an abnormal structure and are resistant to degradation in vitro and in vivo. In the present study, we show that Aβ specifically interacts with fibrinogen with a K(d) of 26.3 ± 6.7 nM, that the binding site is located near the C terminus of the fibrinogen β-chain, and that the binding causes fibrinogen to oligomerize. These results suggest that the interaction between Aβ and fibrinogen modifies fibrinogen's structure, which may then lead to abnormal fibrin clot formation. Overall, our study indicates that the interaction between Aβ and fibrinogen may be an important contributor to the vascular abnormalities found in AD.

PMID:
21098282
[PubMed - indexed for MEDLINE]
PMCID:
PMC3003082
Free PMC Article

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