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J Exp Med. 2010 Nov 22;207(12):2537-41. doi: 10.1084/jem.20102260.

Networking erythropoiesis.

Author information

  • 1Division of Hematology/Oncology, Children's Hospital Boston and the Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

Abstract

A relatively small cadre of lineage-restricted transcription factors largely orchestrates erythropoiesis, but how these nuclear factors interact to regulate this complex biology is still largely unknown. However, recent technological advances, such as chromatin immunoprecipitation (ChIP) paired with massively parallel sequencing (ChIP-seq), gene expression profiling, and comprehensive bioinformatic analyses, offer new insights into the intricacies of red cell molecular circuits.

PMID:
21098097
[PubMed - indexed for MEDLINE]
PMCID:
PMC2989762
Free PMC Article
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