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Conf Proc IEEE Eng Med Biol Soc. 2010;2010:2718-21. doi: 10.1109/IEMBS.2010.5626570.

An integrated, low noise patch-clamp amplifier for biological nanopore applications.

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  • 1Computer Engineering, University of California, Santa Cruz, 1156 High Street, CA 95064, USA.

Abstract

We present an integrated, low noise patch-clamp amplifier for biological nanopore applications. Our amplifier consists of an integrator-differentiator architecture coupled with a novel opamp design in the CMOS 0.35 ┬Ám process. The post-layout full-chip simulation shows the input referred noise of the amplifier is 0.49 pA RMS over a 5 kHz bandwidth using a verified electrical model for the biological nanopore system. In our biological nanopore experiments studying protein-DNA interactions, we encounter capacitive transients with a nominal settling time of 5 ms. Our amplifier design reduces the settling time to 0.2 ms, without requiring any compensation circuitry.

PMID:
21096207
[PubMed - indexed for MEDLINE]
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