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Mol Cell. 2010 Nov 24;40(4):507-8. doi: 10.1016/j.molcel.2010.11.025.

The meaning of pausing.

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  • Department of Molecular, Howard Hughes Medical Institute, The University of Colorado at Boulder, 347 UCB, Boulder, CO 80309-0347, USA. joaquin.espinosa@colorado.edu


Pausing of RNA polymerase II (RNAPII) at the 5' end of genes is a widespread phenomenon in metazoans, but the role of this event in gene regulation is poorly understood. Gilchrist et al. (2010) now demonstrate that RNAPII pausing counteracts DNA-influenced nucleosome organization to allow precise gene activation.

Copyright © 2010 Elsevier Inc. All rights reserved.

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