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Mol Cell. 2010 Nov 24;40(4):503-5. doi: 10.1016/j.molcel.2010.11.019.

A pause to splice.

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  • 1Department of Molecular Biology, Centre for mRNP Biogenesis and Metabolism, CF Møllers Allé 3, Building 1130, Aarhus University, 8000 Aarhus, Denmark.


Maturation of mRNA termini occurs during transcription and can be aided by pausing of RNA polymerase II (RNAPII). In this issue of Molecular Cell, two groups now demonstrate that RNAPII pausing may also assist cotranscriptional splicing in S. cerevisiae.

Copyright © 2010 Elsevier Inc. All rights reserved.

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