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Immunol Allergy Clin North Am. 2011 Feb;31(1):133-40. doi: 10.1016/j.iac.2010.09.013.

The adverse effects of psychological stress on immunoregulatory balance: applications to human inflammatory diseases.

Author information

  • Laboratory of Behavioral Immunology Research, Division of Clinical Immunology and Allergy, Department of Medicine, The University of Mississippi Medical Center, 2500 North State Street N416, Jackson, MS 39216-4505, USA. gmarshall@umc.edu

Abstract

Psychological stress has known effects on the immune system, including impacting effector and regulatory components. This can result in increased susceptibility to various infections, latent virus reactivation, and impact on immunoregulatory circuits. One of the great challenges in translational research is defining the risks associated with stress in specific patient populations and individuals. Future studies must include identification and validation of biomarkers that can categorize patient risk for adverse immune effects from various forms and degrees of psychological stress and how this impacts the course of their inflammatory disease.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21094928
[PubMed - indexed for MEDLINE]
PMCID:
PMC2991159
Free PMC Article
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