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    FEBS Lett. 2011 Jan 3;585(1):148-52. Epub 2010 Nov 19.

    Stat3 is essential for neuronal differentiation through direct transcriptional regulation of the Sox6 gene.

    Snyder M, Huang XY, Zhang JJ.

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    Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10065, USA.

    Abstract

    The transcription factor Signal Transducer and Activator of Transcription 3 (Stat3) functions in various cellular processes including neuronal differentiation. We show that the SRY-box containing gene 6 (Sox6) gene, important for neuronal differentiation, is a direct target gene of Stat3. We demonstrate that in response to ligand stimulation, Stat3 binds to the Sox6 promoter and induces its expression. Furthermore, Stat3 is activated and Sox6 is induced during neuronal differentiation of P19 cells in the absence of exogenous ligand treatment. Moreover, using an RNA interference approach, we show that Stat3 is required for Sox6 expression during neuronal differentiation.

    Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

    PMID:
    21094641
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3022371
    Free PMC Article

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