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Pediatr Neurol. 2010 Dec;43(6):425-6. doi: 10.1016/j.pediatrneurol.2010.06.011.

Influenza A induced acute autonomic neuropathy in an adolescent.

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  • 1Department of Pediatrics, Turku University Hospital, Turku, Finland.


Influenza A may cause serious neurologic complications, but an autoimmune autonomic ganglionopathy has rarely been reported. Autoantibodies that impair synaptic transmission in the autonomic ganglia may cause orthostatic hypotension, gastrointestinal dysmotility, and sudomotor dysfunction. A 15-year-old girl developed severe and persisting orthostatic hypotension during influenza A infection. Removal of circulating antibodies by a single course of intravenous immunoglobulin resulted in rapid and complete recovery.

Copyright © 2010 Elsevier Inc. All rights reserved.

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