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Neuron. 2010 Nov 18;68(4):601-3. doi: 10.1016/j.neuron.2010.11.014.

Sorting out frontotemporal dementia?

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  • 1Center for Translational Research in Neurodegenerative Disease and Department of Neuroscience, College of Medicine, University of Florida, 1275 Center Drive BMS J-483, Gainesville, FL 32610-0244, USA.


Mutations within the granulin (GRN) gene that encodes progranulin (PGRN) cause the neurodegenerative disease frontotemporal lobar degeneration with ubiquitin inclusions (FTLD-U). The receptor for PGRN in the CNS has not been previously identified. In this issue of Neuron, Hu and colleagues identify Sortilin (SORT1) as a key neuronal receptor for PGRN that facilitates its endocytosis and regulates PGRN levels in vitro and in vivo.

Copyright © 2010 Elsevier Inc. All rights reserved.

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