Format

Send to:

Choose Destination
See comment in PubMed Commons below
Neuron. 2010 Nov 18;68(4):601-3. doi: 10.1016/j.neuron.2010.11.014.

Sorting out frontotemporal dementia?

Author information

  • 1Center for Translational Research in Neurodegenerative Disease and Department of Neuroscience, College of Medicine, University of Florida, 1275 Center Drive BMS J-483, Gainesville, FL 32610-0244, USA. jada.lewis@mbi.ufl.edu

Abstract

Mutations within the granulin (GRN) gene that encodes progranulin (PGRN) cause the neurodegenerative disease frontotemporal lobar degeneration with ubiquitin inclusions (FTLD-U). The receptor for PGRN in the CNS has not been previously identified. In this issue of Neuron, Hu and colleagues identify Sortilin (SORT1) as a key neuronal receptor for PGRN that facilitates its endocytosis and regulates PGRN levels in vitro and in vivo.

Copyright © 2010 Elsevier Inc. All rights reserved.

PMID:
21092851
[PubMed]
Free full text

Publication Types

Publication Types

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk