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Genome Biol. 2010;11(11):R112. doi: 10.1186/gb-2010-11-11-r112. Epub 2010 Nov 23.

Patient-oriented gene set analysis for cancer mutation data.

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  • 1Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 N, Wolfe Street, Baltimore, MD 21205, USA.

Abstract

Recent research has revealed complex heterogeneous genomic landscapes in human cancers. However, mutations tend to occur within a core group of pathways and biological processes that can be grouped into gene sets. To better understand the significance of these pathways, we have developed an approach that initially scores each gene set at the patient rather than the gene level. In mutation analysis, these patient-oriented methods are more transparent, interpretable, and statistically powerful than traditional gene-oriented methods.

© 2010 Boca et al.; licensee BioMed Central Ltd.

PMID:
21092299
[PubMed - indexed for MEDLINE]
PMCID:
PMC3156951
Free PMC Article

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