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Department of Orthopaedics, University of Southern California School of Medicine, Los Angeles.
A rapidly growing, malignant schwannoma occurred in a 46-year-old woman with neurofibromatosis. Computed tomography, isotope bone scan, chest roentgenogram, and angiogram are helpful in determining the local extent and distant spread of such musculoskeletal tumors and are useful in planning appropriate surgical management. A well-planned biopsy, however, is essential to accurately determine the histologic diagnosis of the tumor. Clinical and roentgenographic presentation of some benign lesions may mimic malignant tumors. To confirm the diagnosis of a malignant or benign tumor, it is advisable to examine the musculoskeletal tumor histologically before proceeding with the definitive treatment, even if the clinical presentation strongly suggests malignancy.
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