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J Appl Oral Sci. 2010 Sep-Oct;18(5):533-7.

Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis.

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  • 1Department of Operative Dentistry, Federal University of Pelotas, Pelotas, RS, Brazil.

Abstract

OBJECTIVE:

Actinic cheilitis (AC) is a precancerous lesion of the lip vermillion caused by prolonged exposure to ultraviolet light. The aim of this study was to evaluate the effect of 3% diclofenac in 2.5% hyaluronic acid gel in the treatment of AC.

METHODS:

Thirty-four patients with chronic AC were treated twice a day with topical diclofenac during a period of 30 to 180 days. The individuals were followed up every 15 days by means of clinical examination and digital photographic documentation.

RESULTS:

Of the 27 patients that completed the study, 12 (44%) showed complete remission of the whitish plaques and exfoliative areas, and 15 (56%) had partial remission of the clinical picture of cheilitis. The latter group was submitted to excision of the leukoplakic areas which diagnosis varied from mild to moderate epithelial dysplasia.

CONCLUSIONS:

The results suggest a promising role for diclofenac in hyaluronic acid gel in the treatment of AC. This treatment has the advantages of not being invasive and showing few side effects.

PMID:
21085813
[PubMed - indexed for MEDLINE]
PMCID:
PMC4246388
Free PMC Article
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