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Opt Lett. 2010 Nov 15;35(22):3838-40. doi: 10.1364/OL.35.003838.

Microlens array recording of localized retinal responses.

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  • 1Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

Abstract

We designed a rapid functional imager for the parallel recording of localized intrinsic optical signals (IOSs). This imager used a microlens array (MLA)-based illuminator to deliver visible stimulus light and near-infrared (NIR) recording light simultaneously. The parfocal configuration of the stimulus and recording light illumination enabled confocal recording of the stimulus-evoked IOSs. Because the MLA stimulation/recording spots were widely separated on the retina, and only the photoreceptors within the MLA stimulation/recording spots were stimulated, the potential IOS cross talk effect among neighboring retinal areas was minimized. Our experiments revealed robust IOS activities tightly correlated with localized retinal responses.

PMID:
21082014
[PubMed - indexed for MEDLINE]
PMCID:
PMC3001029
Free PMC Article

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