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Chem Commun (Camb). 2011 Jan 21;47(3):944-6. doi: 10.1039/c0cc02924f. Epub 2010 Nov 15.

Screening of a minimal enriched P450 BM3 mutant library for hydroxylation of cyclic and acyclic alkanes.

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  • 1Institute of Technical Biochemistry, Universitaet of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany.


A minimal enriched P450 BM3 library was screened for the ability to oxidize inert cyclic and acyclic alkanes. The F87A/A328V mutant was found to effectively hydroxylate cyclooctane, cyclodecane and cyclododecane. F87V/A328F with high activity towards cyclooctane hydroxylated acyclic n-octane to 2-(R)-octanol (46% ee) with high regioselectivity (92%).

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