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Cancer Genet Cytogenet. 1990 Apr;45(2):245-8.

Sarcomas in three generations of a family with neurofibromatosis.

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  • 1Department of Epidemiology and Social Oncology, Christie Hospital and Holt Radium Institute, Manchester, England.

Abstract

The development of sarcomas in three generations of a family with neurofibromatosis (NF) is described. A 7-month-old boy developed a prostatic rhabdomyosarcoma. Family history revealed that his maternal grandmother had died of a malignant peripheral nerve sheath tumor at age 37 years and had been affected with neurofibromatosis. His mother (aged 36 years) has also developed a malignant peripheral nerve sheath tumor and NF has been confirmed in both mother and son. This family illustrates a cluster of sarcomas associated with NF and shows the importance of thorough investigation of reported family illnesses.

PMID:
2107963
[PubMed - indexed for MEDLINE]
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