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Nat Chem Biol. 2010 Dec;6(12):861-3. doi: 10.1038/nchembio.479.

Grand challenge commentary: Accessing new chemical space for 'undruggable' targets.

Author information

  • 1Chemical Biology Platform, Broad Institute, Cambridge, Massachusetts, USA. sivaram@broadinstitute.org

Abstract

The synthesis and biological annotation of small molecules from underexplored chemical space will play a central role in the development of drugs for challenging targets currently being identified in frontier areas of biological research such as human genetics.

PMID:
21079589
[PubMed - indexed for MEDLINE]
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