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J Am Chem Soc. 2010 Dec 8;132(48):17071-3. doi: 10.1021/ja107783j. Epub 2010 Nov 15.

Light-activated regulation of cofilin dynamics using a photocaged hydrogen peroxide generator.

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  • 1Department of Chemistry, University of California, Berkeley, California 94720, USA.


Hydrogen peroxide (H2O2) can exert diverse signaling and stress responses within living systems depending on its spatial and temporal dynamics. Here we report a new small-molecule probe for producing H2O2 on demand upon photoactivation and its application for optical regulation of cofilin-actin rod formation in living cells. This chemical method offers many potential opportunities for dissecting biological roles for H2O2 as well as remote control of cell behavior via H2O2-mediated pathways.

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