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Bioinformatics. 2011 Jan 15;27(2):272-4. doi: 10.1093/bioinformatics/btq640. Epub 2010 Nov 12.

The uniqueome: a mappability resource for short-tag sequencing.

Author information

  • 1VerdAscend Sciences, West Linn, OR 97068, USA.

Abstract

SUMMARY:

Quantification applications of short-tag sequencing data (such as CNVseq and RNAseq) depend on knowing the uniqueness of specific genomic regions at a given threshold of error. Here, we present the 'uniqueome', a genomic resource for understanding the uniquely mappable proportion of genomic sequences. Pre-computed data are available for human, mouse, fly and worm genomes in both color-space and nucletotide-space, and we demonstrate the utility of this resource as applied to the quantification of RNAseq data.

AVAILABILITY:

Files, scripts and supplementary data are available from http://grimmond.imb.uq.edu.au/uniqueome/; the ISAS uniqueome aligner is freely available from http://www.imagenix.com/.

PMID:
21075741
[PubMed - indexed for MEDLINE]
PMCID:
PMC3018812
Free PMC Article

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