Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cell Host Microbe. 2010 Nov 18;8(5):445-54. doi: 10.1016/j.chom.2010.10.005.

Statins enhance formation of phagocyte extracellular traps.

Author information

  • 1Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract

Statins are inhibitors of 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in cholesterol biosynthesis. Recent clinico-epidemiologic studies correlate patients receiving statin therapy with having reduced mortality associated with severe bacterial infection. Investigating the effect of statins on the innate immune capacity of phagocytic cells against the human pathogen Staphylococcus aureus, we uncovered a beneficial effect of statins on bacterial clearance by phagocytes, although, paradoxically, both phagocytosis and oxidative burst were inhibited. Probing instead for an extracellular mechanism of killing, we found that statins boosted the production of antibacterial DNA-based extracellular traps (ETs) by human and murine neutrophils and also monocytes/macrophages. The effect of statins to induce phagocyte ETs was linked to sterol pathway inhibition. We conclude that a drug therapy taken chronically by millions alters the functional behavior of phagocytic cells, which could have ramifications for susceptibility and response to bacterial infections in these patients.

Copyright © 2010 Elsevier Inc. All rights reserved.

PMID:
21075355
[PubMed - indexed for MEDLINE]
PMCID:
PMC3008410
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk