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Brain Behav Immun. 2011 Jul;25(5):991-9. doi: 10.1016/j.bbi.2010.11.002. Epub 2010 Nov 11.

Subventricular zone microglia transcriptional networks.

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  • 1Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Microglia play an important role in inflammatory diseases of the central nervous system. There is evidence of microglial diversity with distinct phenotypes exhibiting either neuroprotection and repair or neurotoxicity. However the precise molecular mechanisms underlying this diversity are still unknown. Using a model of experimental autoimmune encephalomyelitis (EAE) we performed transcriptional profiling of isolated subventricular zone microglia from the acute and chronic disease phases of EAE. We found that microglia exhibit disease phase specific gene expression signatures, that correspond to unique gene ontology functions and genomic networks. Our data demonstrate for the first time, distinct transcriptional networks of microglia activation in vivo, that suggests a role as mediators of injury or repair.

Copyright © 2010 Elsevier Inc. All rights reserved.

PMID:
21074605
[PubMed - indexed for MEDLINE]
PMCID:
PMC3109092
Free PMC Article

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