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Cytokine Growth Factor Rev. 2010 Dec;21(6):413-23. doi: 10.1016/j.cytogfr.2010.10.002. Epub 2010 Nov 11.

IL-17 family member cytokines: regulation and function in innate immunity.

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  • 1Department of Immunology and Center for Inflammation and Cancer, M.D. Anderson Cancer Center, Houston, TX 77054, USA.


Recently, the IL-17 family member cytokines have become prominent subjects of investigation. IL-17 (IL-17A) is the best-described member of this family where its production has been mainly attributed to a specialized T helper subset of the adaptive immune response termed Th17. However, recent research on this and other Th17 cytokines has revealed new sources and functions of IL-17 family members in the innate immune response. This review will highlight recent advances in the field of IL-17 family member cytokines and will predominantly focus on the innate regulation and function of IL-17, IL-17F, and IL-25.

Copyright © 2010 Elsevier Ltd. All rights reserved.

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