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Cell. 2010 Nov 12;143(4):503-5. doi: 10.1016/j.cell.2010.10.036.

Shining a light on germinal center B cells.

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  • 1Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA.


The mechanisms of B cell selection in lymphoid tissues are poorly understood. In this issue, Victora et al. (2010) use imaging of photoactivatable green fluorescent protein to define the movements of B cells in germinal centers and provide evidence that antibody affinity maturation is driven by competition for T cell help.

Copyright © 2010 Elsevier Inc. All rights reserved.

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