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EMBO Rep. 2010 Dec;11(12):956-61. doi: 10.1038/embor.2010.169. Epub 2010 Nov 12.

Receptor for activated C kinase 1 stimulates nascent polypeptide-dependent translation arrest.

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  • 1Nagoya University, Chikusa-ku, Japan.


Nascent peptide-dependent translation arrest is crucial for the quality control of eukaryotic gene expression. Here we show that the receptor for activated C kinase 1 (RACK1) participates in nascent peptide-dependent translation arrest, and that its binding to the 40S subunit is crucial for this. Translation arrest by a nascent peptide results in Dom34/Hbs1-independent endonucleolytic cleavage of mRNA, and this is stimulated by RACK1. We propose that RACK1 stimulates the translation arrest that is induced by basic amino-acid sequences that leads to endonucleolytic cleavage of the mRNA, as well as to co-translational protein degradation.

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