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Clin Gastroenterol Hepatol. 2011 Apr;9(4):340-3. doi: 10.1016/j.cgh.2010.10.033. Epub 2010 Nov 9.

Rapid development of colorectal neoplasia in patients with Lynch syndrome.

Author information

  • 1Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Abstract

BACKGROUND & AIMS:

Patients with Lynch syndrome have a high risk for colorectal adenomas and carcinomas. We evaluated the development of colorectal neoplasia in these patients.

METHODS:

We assessed serial colonoscopy findings from 54 persons from 29 pedigrees with pathogenic mutations in MSH2 or MLH1; we evaluated the development of colorectal neoplasia by age, sex, tumor location, and number (mean follow-up time, 9.3 years; colonoscopy interval, 1.7 ± 1.2 years; 112 adenomas and 31 cancers). Differences in colorectal phenotype were analyzed by genotype, and dwell time was calculated for advanced neoplasias.

RESULTS:

Among mutation carriers, the cumulative risk of colorectal neoplasia was 43% by age 40 years and 72% by 80 years. There were no statistically significant associations between time to development of colorectal neoplasia and sex or mutation type. Most female patients had left-sided neoplasms, whereas most male patients developed right-sided lesions. The mean cumulative numbers of neoplastic lesions in patients were 1.3 ± 0.5 by age 30 years and 7.6 ± 6.8 by age 80 years. Polyp dwell time was 33.0 ± 16.2 months and 35.2 ± 22.3 months for advanced adenoma and colorectal cancer, respectively. The 5-year survival rate for patients with colorectal cancer was 96%.

CONCLUSIONS:

High percentages of individuals with pathogenic mutations in MSH2 or MLH1 develop colorectal neoplasia by age 40. Left-sided colorectal neoplasias are more frequent in female patients. The development of 3 or more colorectal neoplasms by age 30 years indicates a possible polyposis syndrome rather than Lynch syndrome. Polyp dwell time is short for advanced neoplasias, arguing for annual colonoscopic screening and surveillance.

Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.

Comment in

  • Speed kills. [Clin Gastroenterol Hepatol. 2011]
PMID:
21070872
[PubMed - indexed for MEDLINE]
PMCID:
PMC3073674
Free PMC Article
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