Abstract
O,O-Dimethylthiophosphonosulfenyl bromide (DMTPSB) in combination with silver triflate provides a powerful thiophilic promoter system. Both "armed" and "disarmed" thioglycoside glycosyl donors can be activated to form glycosidic linkages efficiently by the pre-activation protocol. The usefulness of this new promoter is illustrated by a successful iterative one-pot oligosaccharide assembly.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bromides / chemistry*
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Glycosylation
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Mesylates / chemistry*
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Molecular Structure
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Oligosaccharides / chemistry
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Organothiophosphorus Compounds / chemistry*
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Silver Compounds / chemistry*
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Thioglycosides / chemistry*
Substances
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Bromides
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Mesylates
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O,O-dimethylthiophosphonosulfenyl bromide-silver triflate
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Oligosaccharides
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Organothiophosphorus Compounds
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Silver Compounds
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Thioglycosides
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silver bromide