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Cold Spring Harb Perspect Biol. 2010 Dec;2(12):a000711. doi: 10.1101/cshperspect.a000711. Epub 2010 Nov 10.

Biogenesis of nuclear bodies.

Author information

  • 1Department of Cell Biology, Rosalind Franklin University of Medicine and Science, North Chicago, Ilinois 60064, USA. mirek.dundr@rosalindfranklin.edu

Abstract

The nucleus is unique amongst cellular organelles in that it contains a myriad of discrete suborganelles. These nuclear bodies are morphologically and molecularly distinct entities, and they host specific nuclear processes. Although the mode of biogenesis appears to differ widely between individual nuclear bodies, several common design principles are emerging, particularly, the ability of nuclear bodies to form de novo, a role of RNA as a structural element and self-organization as a mode of formation. The controlled biogenesis of nuclear bodies is essential for faithful maintenance of nuclear architecture during the cell cycle and is an important part of cellular responses to intra- and extracellular events.

PMID:
21068152
[PubMed - indexed for MEDLINE]
PMCID:
PMC2982170
Free PMC Article

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