Format

Send to:

Choose Destination
See comment in PubMed Commons below
Tuberculosis (Edinb). 2011 Jan;91(1):82-5. doi: 10.1016/j.tube.2010.09.007. Epub 2010 Nov 9.

Aerosol vaccines for tuberculosis: a fine line between protection and pathology.

Author information

  • 1Aeras Global TB Vaccine Foundation, Vaccine Assessment, 1405 Research Boulevard, Suite 300, Rockville, MD 20850, USA. dhokey@aeras.org

Abstract

Pulmonary delivery of vaccines against airborne infection is being investigated worldwide, but there is limited effort directed at developing inhaled vaccines for tuberculosis (TB). This review addresses some of the challenges confronting vaccine development for TB and attempts to link these challenges to the promises of mucosal immunity offered by pulmonary delivery. There are several approaches working toward this goal including subunit vaccines, recombinant strains, a novel vaccine strain Mycobacterium w, and DNA vaccine approaches. While it is clear that lung-resident adaptive immunity is an attainable goal, vaccine platforms must ensure that damage to the lung is limited during both vaccination and when memory cells respond to pathogenic infection.

Copyright © 2010 Elsevier Ltd. All rights reserved.

PMID:
21067975
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk