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Trends Immunol. 2011 Jan;32(1):19-25. doi: 10.1016/j.it.2010.10.002. Epub 2010 Nov 8.

Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function.

Author information

  • 1H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Fl 33612, USA.

Abstract

Myeloid-derived suppressor cells (MDSCs) are one of the main cell populations responsible for regulating immune responses. MDSCs accumulate during tumor progression, autoimmunity, chronic infection and other pathological conditions, and can potently suppress T cell function. Recent studies have demonstrated the ability of MDSCs to modulate the activity of NK and myeloid cells and have implicated MDSCs in the induction of regulatory T cells. Here, we discuss recent findings that describe the molecular mechanisms that regulate the expansion and function of MDSCs, as well as recent attempts to use MDSCs in cell therapy for different pathologic conditions.

Copyright © 2010 Elsevier Ltd. All rights reserved.

PMID:
21067974
[PubMed - indexed for MEDLINE]
PMCID:
PMC3053028
Free PMC Article

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