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    Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20587-92. Epub 2010 Nov 8.

    Physiological and pathological population dynamics of circulating human red blood cells.

    Higgins JM, Mahadevan L.

    Source

    Center for Systems Biology and Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA. john_higgins@hms.harvard.edu

    Abstract

    The systems controlling the number, size, and hemoglobin concentrations of populations of human red blood cells (RBCs), and their dysregulation in anemia, are poorly understood. After release from the bone marrow, RBCs undergo reduction in both volume and total hemoglobin content by an unknown mechanism [Lew VL, et al. (1995) Blood 86:334-341; Waugh RE, et al. (1992) Blood 79:1351-1358]; after ∼120 d, responding to an unknown trigger, they are removed. We used theory from statistical physics and data from the hospital clinical laboratory [d'Onofrio G, et al. (1995) Blood 85:818-823] to develop a master equation model for RBC maturation and clearance. The model accurately identifies patients with anemia and distinguishes thalassemia-trait anemia from iron-deficiency anemia. Strikingly, it also identifies many pre-anemic patients several weeks before anemia becomes clinically detectable. More generally we illustrate how clinical laboratory data can be used to develop and to test a dynamic model of human pathophysiology with potential clinical utility.

    PMID:
    21059904
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2996693
    Free PMC Article

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