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Psychiatr Danub. 2010 Nov;22 Suppl 1:S132-4.

Natural killer cell cytotoxity and course of illness in depressed mood.

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  • 1Université catholique de Louvain, Cliniques universitaires de Mont-Godinne, 5530 Yvoir, Belgium.


There is now some evidence that depressed mood is associated with activation of the immune system. First, we evaluated, within a cross-sectional design, NKCA (in vitro) in 49 subjects meeting inclusion criteria either for a major depressive episode, for dysthymia, or for "double depression". We found that recent and long depressive episodes (dysthymia) are associated with a lower immunodepression. Second, we compared two subset of subjects: 14 patients meeting criteria of major depression to 14 healthy controls. The data show a significant improvement in major depression when compared to controls througout a treatment combining supportive psychotherapy and 8 mg Reboxetineâ„¢.

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