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    Appl Environ Microbiol. 2011 Jan;77(1):330-4. Epub 2010 Nov 5.

    Stability and tick transmission phenotype of gfp-transformed Anaplasma marginale through a complete in vivo infection cycle.

    Noh SM, Ueti MW, Palmer GH, Munderloh UG, Felsheim RF, Brayton KA.

    Source

    Animal Disease Research Unit, Agriculture Research Service, US Department of Agriculture, Pullman, WA 99164-7030, USA. snoh@vetmed.wsu.edu

    Abstract

    We tested the stability and tick transmission phenotype of transformed Anaplasma marginale through a complete in vivo infection cycle. Similar to the wild type, the gfp-transformed A. marginale strain established infection in cattle, a natural reservoir host, and persisted in immune competent animals. The tick infection rates for the transformed A. marginale and the wild type were the same. However, there were significantly lower levels of the transformed A. marginale than of the wild type in the tick. Despite the lower levels of replication, ticks transmitted the transformant. Transformants can serve as valuable tools to dissect the molecular requirements of tick colonization and pathogen transmission.

    PMID:
    21057014
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3019711
    Free PMC Article

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