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J Vet Intern Med. 2010 Nov-Dec;24(6):1305-13. doi: 10.1111/j.1939-1676.2010.0629.x.

Characterization and mode of inheritance of a paroxysmal dyskinesia in Chinook dogs.

Author information

  • 1Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO, USA. rpacker@purdue.edu

Abstract

BACKGROUND:

Paroxysmal dyskinesias are episodes of abnormal, involuntary movement or muscle tone, distinguished from seizures by the character of the episode and lack of seizure activity on ictal EEG.

HYPOTHESIS:

Paroxysmal dyskinesia is an inherited, autosomal recessive disorder in Chinook dogs.

ANIMALS:

Families of Chinook dogs with paroxysmal dyskinesia.

METHODS:

Pedigrees and medical histories were reviewed for 299 Chinook dogs. A family of 51 dogs was used for analysis. Episodes were classified as seizures, paroxysmal dyskinesia, or unknown, and segregation analysis was performed.

RESULTS:

Paroxysmal dyskinesia was identified in 16 of 51 dogs and characterized by an inability to stand or ambulate, head tremors, and involuntary flexion of 1 or multiple limbs, without autonomic signs or loss of consciousness. Episode duration varied from minutes to an hour. Inter-ictal EEGs recorded on 2 dogs with dyskinesia were normal. Three dogs with dyskinesia also had generalized tonic-clonic seizures. One of 51 dogs had episodes of undetermined type. Phenotype was unknown for 6 of 51 dogs, and 28 dogs were unaffected. Segregation was consistent with an autosomal recessive trait.

CONCLUSIONS AND CLINICAL IMPORTANCE:

This movement disorder is prevalent in the Chinook breed, and consistent with a partially penetrant autosomal recessive or polygenic trait. Insufficient evidence exists for definitive localization; episodes may be of basal nuclear origin, but atypical seizures and muscle membrane disorders remain possible etiologies. The generalized seizures may be a variant phenotype of the same mutation that results in dyskinesia, or the 2 syndromes may be independent.

Copyright © 2010 by the American College of Veterinary Internal Medicine.

PMID:
21054538
[PubMed - indexed for MEDLINE]
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