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J Am Geriatr Soc. 2010 Nov;58(11):2055-62. doi: 10.1111/j.1532-5415.2010.03145.x.

Loss of muscle strength, mass (sarcopenia), and quality (specific force) and its relationship with functional limitation and physical disability: the Concord Health and Ageing in Men Project.

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  • 1Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. noran@um.edu.my

Abstract

OBJECTIVES:

To determine the association between loss of muscle strength, mass, and quality and functional limitation and physical disability in older men.

DESIGN:

Cross-sectional study of older men participating in the Concord Health and Ageing in Men Project (CHAMP).

SETTING:

Elderly men living in a defined geographical region in Sydney, Australia.

PARTICIPANTS:

One thousand seven hundred five community-dwelling men aged 70 and older who participated in the baseline assessments of CHAMP.

MEASUREMENTS:

Upper and lower extremity strength were measured using dynamometers for grip and quadriceps strength. Appendicular skeletal lean mass was assessed using dual X-ray absorptiometry. Muscle quality was defined as the ratio of strength to mass in upper and lower extremities. For each parameter, subjects in the lowest 20% of the distribution were defined as below normal. Functional limitation was assessed according to self-report and objective lower extremity performance measures. Physical disability was measured according to self-report questionnaire.

RESULTS:

After adjusting for important confounders, the prevalence ratio (PR) for poor quadriceps strength and self-reported functional limitation was 1.91 (95% confidence interval (CI) = 1.10-2.40); for performance-based functional limitation the PR was 1.81 (95% CI = 1.45-2.24). The adjusted PR for poor grip strength and physical disability in instrumental activities of daily living (IADLs) was 1.37 (95% CI = 1.20-1.56). The adjusted PR for low skeletal lean mass (adjusted for fat mass) and physical disability in basic activities of daily living was 2.08 (95% CI = 1.37-3.15). For muscle quality, the PR for lower extremity specific force and functional limitation and physical disability was stronger than upper extremity specific force.

CONCLUSION:

Muscle strength is the single best measure of age-related muscle change and is associated with physical disability in IADLs and functional limitation.

© 2010, Copyright the Authors. Journal compilation © 2010, The American Geriatrics Society.

PMID:
21054284
[PubMed - indexed for MEDLINE]
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