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Acta Cytol. 2010 Sep-Oct;54(5 Suppl):985-8.

Cytohistomorphologic features of malignant fibrous histiocytoma of the breast: a case report.

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  • 1Department of Pathology, Lady Hardinge Medical College and Shrimati Sucheta Kriplani Hospital, New Delhi-1 10001, India.



Malignant mesenchymal tumors constitute < 1% of all malignant neoplasms of the breast. These include pure primary sarcoma of the breast, metastatic sarcoma and sarcomatous patterns in metaplastic carcinomas. On fine needle aspiration cytology (FNAC), the cellular features can suggest the diagnosis of sarcoma of the breast, although the potential exists for confusion with very poorly differentiated carcinoma.


A case of recurrent primary malignant fibrous histiocytoma (MFH) occurred in the breast in a 32-year-old woman. The patient presented with a fungating mass in the right breast. FNAC was suggestive of malignant mesenchymal tumor, most probably MFH. The diagnosis was confirmed on biopsy.


Malignant fibrous histiocytoma of the breast is a rare entity, and a complete clinicopathologic correlation with immunohistochemical profile is essential to arrive at a correct diagnosis and guide appropriate management of the patient.

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