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Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):123-33. doi: 10.1158/1055-9965.EPI-10-0988. Epub 2010 Nov 4.

Efficacy of exercise interventions in modulating cancer-related fatigue among adult cancer survivors: a meta-analysis.

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  • 1Department of Kinesiology, University of Connecticut, 2095 N. Hillside Road, U-1110, Storrs, CT 06269, USA. justin.brown@uconn.edu

Abstract

BACKGROUND:

The purpose of this meta-analysis was to explore the efficacy of exercise as a nonpharmacologic intervention to reduce cancer-related fatigue (CRF) among adult cancer survivors. We also investigated how different components of the exercise prescription (Ex R(x)), methodologic considerations, and subject characteristics modulate CRF.

METHODS:

A systematic search for randomized controlled trials was conducted using words related to cancer, exercise, and fatigue.

RESULTS:

In total, 44 studies with 48 interventions qualified, including 3,254 participants of varying cancer types, stages of diagnosis, treatments, and exercise interventions. Cancer survivors in exercise interventions reduced their CRF levels to a greater extent than usual care controls, d(+) = 0.31 (95% CI = 0.22-0.40), an effect that appeared to generalize across several types of cancer. CRF levels improved in direct proportion to the intensity of resistance exercise (β = 0.60, P = 0.01), a pattern that was stronger in higher quality studies (β = 0.23, P < 0.05). CRF levels also reduced to a greater extent when interventions were theoretically driven (β = 0.48, P < 0.001) or cancer survivors were older (β = 0.24, P = 0.04).

CONCLUSIONS:

Exercise reduced CRF especially in programs that involved moderate-intensity, resistance exercise among older cancer survivors and that were guided by theory.

IMPACT:

Our results indicate exercise interventions for adult cancer survivors should be multi-dimensional and individualized according to health outcome and cancer type.

©2011 AACR.

PMID:
21051654
[PubMed - indexed for MEDLINE]
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