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J Allergy Clin Immunol. 2010 Dec;126(6):1157-62. doi: 10.1016/j.jaci.2010.09.011. Epub 2010 Nov 4.

Early childhood weight status in relation to asthma development in high-risk children.

Author information

  • 1Department of Nutritional Sciences, University of Wisconsin College of Agriculture and Life Sciences, Madison, WI 53706-1562, USA. zhuminzhang@wisc.edu

Abstract

BACKGROUND:

Obesity has been proposed to be a risk factor for the development of childhood asthma.

OBJECTIVE:

We sought to examine weight status from birth to age 5 years in relation to the occurrence of asthma at ages 6 and 8 years.

METHODS:

Two hundred eighty-five full-term high-risk newborns with at least 1 asthmatic/atopic parent enrolled in the Childhood Origin of Asthma project were studied from birth to age 8 years. Overweight was defined by weight-for-length percentiles of greater than the 85th percentile before the age of 2 years and a body mass index percentile of greater than the 85th percentile at ages 2 to 5 years.

RESULTS:

No significant concurrent association was found between overweight status and wheezing/asthma occurrence at each year of age. In contrast, longitudinal analyses revealed complex relationships between being overweight and asthma. Being overweight at age 1 year was associated with a decreased risk of asthma at age 6 (odds ratio [OR], 0.32; P = .02) and 8 (OR, 0.35; P = .04) years, as well as better lung function. However, being overweight beyond infancy was not associated with asthma occurrence. In fact, only children who were overweight at age 5 years but not at age 1 year had an increased risk of asthma at age 6 years (OR, 5.78; P = .05).

CONCLUSION:

In children genetically at high risk of asthma, being overweight at age 1 year was associated with a decreased risk of asthma and better lung function at ages 6 and 8 years. However, being overweight beyond infancy did not have any protective effect and even could confer a higher risk for asthma.

Copyright © 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

PMID:
21051081
[PubMed - indexed for MEDLINE]
PMCID:
PMC2998556
Free PMC Article
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