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Annu Rev Genet. 2010;44:393-417. doi: 10.1146/annurev-genet-102209-163602.

The RecQ DNA helicases in DNA repair.

Author information

  • 1Columbia University Medical Center, Department of Genetics & Development, New York, New York 10032, USA. kab2142@columbia.edu

Abstract

The RecQ helicases are conserved from bacteria to humans and play a critical role in genome stability. In humans, loss of RecQ gene function is associated with cancer predisposition and/or premature aging. Recent experiments have shown that the RecQ helicases function during distinct steps during DNA repair; DNA end resection, displacement-loop (D-loop) processing, branch migration, and resolution of double Holliday junctions (dHJs). RecQ function in these different processing steps has important implications for its role in repair of double-strand breaks (DSBs) that occur during DNA replication and meiosis, as well as at specific genomic loci such as telomeres.

PMID:
21047263
[PubMed - indexed for MEDLINE]
PMCID:
PMC4038414
Free PMC Article

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