Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Annu Rev Genet. 2010;44:293-308. doi: 10.1146/annurev-genet-102209-163421.

Rare variant association analysis methods for complex traits.

Author information

  • 1Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom.


There has been increasing interest in rare variants and their association with disease, and several rare variant-disease associations have already been detected. The usual association tests for common variants are underpowered for detecting variants of lower frequency, so alternative approaches are required. In addition to reviewing the association analysis methods for rare variants, we discuss the limitations of genome-wide association studies in identifying rare variants and the problems that arise in the imputation of rare variants.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Write to the Help Desk