Mol Cell Biol. 1990 Jan;10(1):397-400.

Copy choice mechanism of immunoglobulin heavy-chain switch recombination.

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Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109-0620.

Abstract

The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated with donor and recipient constant-region genes. We have determined that the mutations which can be found in some switch regions after recombination appear to arise on only one strand of DNA. This result suggests that switch recombination involves error-prone synthesis of one DNA strand and ligation of the other strand from preexisting DNA.

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PMCID:: PMC360764

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Class switch from mu to delta is mediated by homologous recombination between sigma mu and sigma mu sequences in human immunoglobulin gene loci. [Eur J Immunol. 1989]
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Cited by 19 PubMed Central articles

Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions. [J Exp Med. 2004]
Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions.
Zeng X, Negrete GA, Kasmer C, Yang WW, Gearhart PJ. J Exp Med. 2004 Apr 5; 199(7):917-24. Epub 2004 Mar 29.
Mapping of a functional recombination motif that defines isotype specificity for mu-->gamma3 switch recombination implicates NF-kappaB p50 as the isotype-specific switching factor. [J Exp Med. 2004]
Mapping of a functional recombination motif that defines isotype specificity for mu-->gamma3 switch recombination implicates NF-kappaB p50 as the isotype-specific switching factor.
Kenter AL, Wuerffel R, Dominguez C, Shanmugam A, Zhang H. J Exp Med. 2004 Mar 1; 199(5):617-27.
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination. [EMBO J. 2003]
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination.
Schrader CE, Bradley SP, Vardo J, Mochegova SN, Flanagan E, Stavnezer J. EMBO J. 2003 Nov 3; 22(21):5893-903.

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