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Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt 11):1421-5. doi: 10.1107/S1744309110036286. Epub 2010 Oct 27.

The homodimeric GBS1074 from Streptococcus agalactiae.

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  • 1School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, England.

Abstract

ESAT-6 is a well characterized secreted protein from Mycobacterium tuberculosis and represents the archetype of the WXG100 family of proteins. Genes encoding ESAT-6 homologues have been identified in the genome of the human pathogen Streptococcus agalactiae; one of these genes, esxA, has been cloned and the recombinant protein has been crystallized. In contrast to M. tuberculosis ESAT-6, the crystal structure of GBS1074 reveals a homodimeric structure similar to homologous structures from Staphylococcus aureus and Helicobacter pylori. Intriguingly, GBS1074 forms elongated fibre-like assemblies in the crystal structure.

PMID:
21045286
[PubMed - indexed for MEDLINE]
PMCID:
PMC3001639
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