Bipolar Disord. 2010 Nov;12(7):702-6. doi: 10.1111/j.1399-5618.2010.00864.x.

The pharmacogenetics of antidepressant-induced mania: a systematic review and meta-analysis.

Source

Hospital Neuropsiquiátrico Braulio A. Moyano, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.

Abstract

OBJECTIVE:

Antidepressant-induced mania (AIM) has been associated with the serotonin-transporter-linked promoter region (5-HTTLPR) polymorphism in some studies but not in others. We conducted a meta-analysis of those studies and other studies of genetic predictors of AIM.

METHODS:

MEDLINE-based searches of genetic studies of AIM were conducted, and a meta-analysis of six studies of 5-HTTLPR was performed. Other polymorphisms were insufficiently studied to allow for meta-analysis.

RESULTS:

There was an association of the short (s) variant of 5-HTTLPR and AIM [risk ratio (RR) = 1.35, 95% confidence interval (CI): 1.04-1.76, p=0.02]. There was a higher frequency of s carriers (sl and ss genotypes) in those who developed AIM [RR = 1.38, 95% CI: 0.98-1.93), p=0.06].

CONCLUSION:

The 5-HTTLPR polymorphism appears to have a moderate effect size association with AIM in patients with bipolar disorder.

PMID:: 21040287; [PubMed - indexed for MEDLINE]

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