Kidney Int. 2010 Nov;78(10):951-3.

IgG4-related tubulointerstitial nephritis.

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Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. cornell@alum.mit.edu

Abstract

Tubulointerstitial nephritis (TIN) is a disease pattern with heterogeneous causes. Recently a specific subtype of autoimmune TIN, IgG4-related TIN, has been identified that is part of systemic IgG4-related disease/ autoimmune pancreatitis. On biopsy, this TIN shows an IgG4+ plasma cell-rich infiltrate, akin to the pancreatic tissue findings in autoimmune pancreatitis, and may show tubulointerstitial immune complex deposits. Notably, some cases may be mass-forming. Recognition of this specific type of TIN can guide appropriate patient therapy.

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Kidney Int. 2010 Nov;78(10):1016-23.

PMID:: 21030970; [PubMed - indexed for MEDLINE]

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