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Immunol Allergy Clin North Am. 2010 Nov;30(4):553-63, vii. doi: 10.1016/j.iac.2010.08.002.

Virus/allergen interactions and exacerbations of asthma.

Author information

  • 1Department of Pediatrics, University of Wisconsin-Madison School of Medicine and Public Health, K4/910 CSC 9988, 600 Highland Avenue, Madison, WI 53792, USA. kkloepfer@medicine.wisc.edu

Abstract

Clinical research findings indicate that there are synergistic interactions between allergy and viral infection that cause increased severity of asthma exacerbations. This article summarizes the current literature linking these 2 risk factors for asthma exacerbation, and reviews experimental data suggesting potential mechanisms for interactions between viral infection and allergy that cause asthma exacerbations. In addition, the authors discuss clinical evidence that treatment of allergic inflammation could help to reduce the frequency and severity of virus-induced exacerbations of asthma.

Copyright © 2010 Elsevier Inc. All rights reserved.

PMID:
21029938
[PubMed - indexed for MEDLINE]
PMCID:
PMC3001159
Free PMC Article
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