Hb Davenport or alpha 2(78)(EF7)Asn----His beta 2

Hemoglobin. 1990;14(6):599-605. doi: 10.3109/03630269009046968.

Abstract

Hb Davenport is a new, stable alpha chain variant, that was detected in two members of a Caucasian family living in Iowa. Hematological data were within normal limits. It is characterized by an Asn----His replacement at position alpha 78. Mild acidic hydrolysis of the large alpha T-9 peptide, separation of the resulting fragments by reversed phase high performance liquid chromatography, and sequence analysis of a few of these peptides greatly facilitated the identification of this substitution.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Amino Acids / analysis
  • Asparagine / genetics
  • Female
  • Hemoglobins, Abnormal / chemistry*
  • Hemoglobins, Abnormal / genetics
  • Histidine / genetics
  • Humans
  • Infant
  • Molecular Sequence Data
  • Mutation

Substances

  • Amino Acids
  • Hemoglobins, Abnormal
  • hemoglobin Davenport
  • Histidine
  • Asparagine