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1: J Pharm Biomed Anal. 1990;8(8-12):717-20.Click here to read Links

The application of Fourier-transform Raman spectroscopy to the analysis of pharmaceuticals and biomaterials.

Tudor AM, Melia CD, Binns JS, Hendra PJ, Church S, Davies MC.

Department of Pharmaceutical Sciences, University of Nottingham, UK.

Near infrared Fourier-transform (FT) Raman spectroscopy is shown to be a useful spectroscopic tool for the molecular structural analysis of drugs and biomedical polymers. The technique has been applied to the non-invasive investigation of the hydrolytic degradation of a biodegradable polymer in water over a period of 15 days and to the analysis of a drug within a polymer vehicle over a wide drug concentration range. This work demonstrates the potential value of FT Raman spectroscopy in the field of pharmaceutical science.

PMID: 2100613 [PubMed - indexed for MEDLINE]