An epidemiological survey was made on Clonorchiasis sinensis for the first time in 17 counties/cities of Hubei Province in 1988. The pathogen of clonorchiasis sinensis was found in 14 of the 17 counties/cities. Individual examination of some population was carried out and in 7 counties/cities, all the people were found to be infected. The infection rate was more than 10% in some of the places surveyed. Most of the cases were youngsters. The chief mode of infection was the habit of eating undercooked fish or holding fish in the mouth. These results showed that Clonorchiasis sinensis infection has been widespread in Hubei Province and in some areas the infection was serious attention should therefore be paid to its control without delay.